Drinking Alcohol and Breast Cancer: Alcohol Consumption as a Risk Factor

The National Institute on Alcohol Abuse and Alcoholism has conducted an exhaustive analysis of the scientific medical evidence regarding alcohol and breast cancer. It concludes that "The effect of alcohol on the risk for breast cancer remains controversial" and describes it as "inconclusive." 1 Consistent with this conclusion, the National Cancer Institute does not include alcohol consumption as a risk factor in its Breast Cancer Risk Assessment Tool. 2

Some studies have found a correlation between alcohol and breast cancer. The association is typically, although not always, described variously as "modest," 3 "minor," 4 "weak," 5 "generally weak," 6 "relatively weak," 7 "small" 8 and "very small." 9 Some studies have found no association between drinking alcohol, especially at moderate levels, and breast cancer. 10 Other scientific studies have found that drinking alcohol in moderation is associated with a reduction of breast cancer risk. 11

The nature and inconsistency of the evidence 12 has called into question the existence of any causal link between moderate alcohol consumption and breast cancer.

Fortunately, the risk of breast cancer is low. "A typical 50-year-old woman has a five-year breast cancer risk of about 3 percent. If her risk jumps by 30 percent, her individual risk is still only about 4 percent." 13 The risk of dying from heart disease is about ten to twelve times greater than dying from breast cancer among women in the U.S.

It appears that drinking alcohol increases the risk of invasive ductal carcinoma, a major form of breast cancer. However, there is no evidence that it increases the risk of

  • Cancer ribbonInflammatory breast cancer (the most aggressive and dangerous breast cancer), 14
  • Basal-like carcinoma breast cancer, 15
  • Invasive lobular carcinoma breast cancer, 16
  • Medullary carcinoma breast cancer, 17
  • Mucinous carcinoma breast cancer, 18
  • Pagets disease (cancer) of the nipple, 19
  • Phyllodes breast tumors, 20
  • Triple-negative breast cancer, 21
  • Adenoid cystic carcinoma of the breast, 22
  • Papillary carcinoma of the breast, 23
  • Ductal carcinoma in situ (DCIS) breast cancer, 24
  • Hereditary breast cancer, 25
  • Metaplastic breast cancer, 26 or
  • Male breast cancer. 27

There is scientific evidence that adequate consumption of Vitamin B-9 (folate or folic acid) may eliminate any risk of breast cancers associated with drinking alcohol. An exhaustive review of the research evidence has found that women who drink alcohol and have a high folate intake are not at increased risk of breast cancers compared to those who abstain from alcohol. 28

An example of the evidence comes for a study of over 17,000 Australian women aged 40-69 over a period of about ten years. Women who consumed 40 grams of alcohol per day (about three drinks) and took 200 micrograms of Vitamin B9 every day, had a lower risk of breast cancers than did women who abstained from alcohol. 29

Foods rich in folate include citrus fruits, citrus juices, dark green leafy vegetables, dried beans, and peas. Most daily multiple-vitamin tablets also contain Vitamin B9. 30

About 50% of women in the U.S. die from cardiovascular heart diseases (CHD) and about 5% die from breast cancer. That means that the average woman's risk of dying from heart disease or stroke is about ten times higher than her risk of dying from breast cancer.

It is important to balance the risk of cardiovascular diseases against the risk of breast cancer. Unless contraindicated, drinking in moderation is associated with better health and greater longevity but there is no best answer for everyone. Therefore, women should consult their health care providers to discuss their risk factors for these and other diseases based on their own specific genetic background, health, environment and life style.

In the words of the National Institute on Alcohol Abuse and Alcoholism,"Individual women, with the help of their physicians, must weigh their potential increased risk for breast cancer against their potential reduced risk for CHD in determining whether alcohol consumption should be reduced." 31

Regardless of a woman's decision, three things that contribute significantly to better health in general are (1) not to smoke, (2) not to be overweight and (3) to exercise regularly.

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) recommends that a woman consume no more than three drinks in any one day and an average of no more than seven drinks per week.

A standard alcoholic drink is:

  • A 12-ounce can or bottle of regular beer
  • A 5-ounce glass of dinner wine
  • A shot (one and one-half ounces) of 80 proof liquor or spirits such as vodka, tequila, or rum either straight or in a mixed drink.

Standard drinks contain equivalent amounts of alcohol. To a breathalyzer, they're all the same.

There is no evidence that any form of alcohol (beer, wine, or liquor - distilled spirits) confers greater health benefits than an other.

 

Note: This website is for general information only and does not provide medical/health opinion or advice and none should be inferred. Always consult a qualified medical care provider to discuss your specific circumstances.

Readings on Alcohol and Breast Cancer:

  • (Listing does not imply endorsement)
  • A clearer understanding of breast cancer risk and alcohol. Mayo Clinic Health Letter, September 2002, 20(9), 4.
  • Alcohol and breast cancer. Harvard Health Letter, 1998, 23(6), 8.
  • Alcohol and breast cancer analysis. The Lancet, 1998, 9102, 575.
  • Alcohol consumption and risk of breast cancer. International Clinical Nutrition Review, 2000, 20(2). 96.
  • Baglietto, L., et al. Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study. British Medical Journal (clinical research edition), 2005, 331(7520), 807.
  • Bailey, L.B. Folate, methyl-related nutrients, alcohol and the MTHFR 677C -->T polymorphous affect cancer risk: intake recommendations. Journal of Nutrition, 2003, 133, 37485-37535.
  • Ballagh, S.A. Alcohol: the link between hormone replacement and breast cancer risk - The critical role of alcohol consumption in determining the risk ofbreast ;cancer with postmenopausal estrogen administration. Women's Health Issues, 1999, 9(6), 338-342.
  • Baumgartner, Kathy .B., et al. Is alcohol intake associated with breast cancer in Hispanic women? The New Mexico Women's Health Study. Ethnicity & Disease, 2002, 12(4), 460-469.
  • Baumgartner, Kathy B. Alcohol Consumption and Breast Cancer Risk among Hispanic and non-Hispanic White Women in New Mexico. Thesis. Houston, TX: University of Texas, 1999.
  • Berstad, Paula, et al. Alcohol intake and breast cancer risk among young women. Breast Cancer Research and Treatment, 2008, 108(1), 113-120.
  • Bessaoud, F., and Daures, J.P. Patterns of alcohol (especially wine) consumption and breast cancer risk: a case-control study among a population in southern France. Annals of Epidemiology, 2008, 18(6), 467-475.
  • Bissonauth, Vishnee, et al. Risk of breast cancer among French-Canadian women, noncarriers of more frequent BRCA1/2 mutations and consumption of total energy, coffee, and alcohol. Breast Journal, 2009, 15( Supp.1), S63-S71.
  • Bowlin S. J., Leske M. C., Varma A., Nasca P., Weinstein A., Caplan L. Breast cancer risk and alcohol consumption: results from a large case-control study. International Journal of Cancer. 1997; 26:915-923.
  • Breast cancer and alcohol intake. Australian Journal of Medical Herbalism, 1998, 10(4), 148.
  • Chen, W.Y., et al. Use of postmenopausal hormones, alcohol, and risk of invasive breast cancer. Annals of Internal Medicine, 2002, 137(10), 798-804.
  • Coutelle, C., et al. Risk factors in alcohol associated breast cancer: Alcohol dehydrogenase polymorphism and estrogens. International Journal of Oncology, 2004, 25(4), 1127-1132.
  • Deandrea, S., et al. Alcohol and breast cancer risk defined by estrogen and progesterone receptor status: a case-control study. Cancer Epidemiology, Biomarkers & Prevention, 2008, 17(8), 2025.
  • Duffy, C.M., et al. Alcohol and folate intake and breast cancer risk in the WHI Observational Study. Breast Cancer Research and Treatment, 2009, 116(3), 551-563.
  • Dumitrescu, Ramona G. and Shields, Peter G. The etiology of alcohol-induced breast cancer. Alcohol, 2005, 34(9), 213.
  • Ellison, R.C., et al. Exploring the relation of alcohol consumption to risk of breast cancer. American Journal of Epidemiology, 2001, 154(8), 740-747.
  • Enger, S.M., et al. Alcohol consumption and breast cancer oestrogen and progesterone receptor status. British Journal of Cancer, 1999, 79(7-8), 1308-1314.
  • Ericson, Ulrika, et al. High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort. American Journal of Clinical Nutrition, 2007, 86(2), 434.
  • Ferraroni, M., et al. Alcohol consumption and risk of breast cancer: a multicentre Italian case-control study. European Journal of Cancer, 1998, 34(9), 1403-1409.
  • Fleischer, Wendy. The Association between Alcohol Consumption and Breast Cancer, Stratified by Predicted BRCA1/BRCA2 Mutation Carier Status. Thesis. New Haven, CT: Yale University, 1999.
  • Franceschi, Silvia, et al. Alcohol consumption and survival after breast cancer. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, 2009, 18(3), 1011.
  • Franceschi, Silvia, et al. Alcohol and breast cancer in young Italian women. Epidemiology, 1998, 9(2), 215.
  • Freudenheim, Jo L. Lifetime Alcohol Exposure and Breast Cancer Risk. Ft. Belvoir: Defense Technical Information Center, 2000.
  • Freudenheim, Jo L., et al. Alcohol dehydrogenase 3 genotype modification of the association of alcohol consumption wit breast cancer. Cancer Causes and Control, 1999, 10(5), 369.
  • Freudenheim J. L., Marshall J. R., Graham S., et al. Lifetime alcohol consumption and risk of breast cancer. Nutrition Cancer. 1995; 23:1-11.
  • Gallus, S., et al. Alcohol postmenopausal hormones, and breast cancer. Annals of Internal Medicine, 2003, 139(7), 601-602.
  • Garland, Miriam, et al. Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age. Cancer Epidemiology, Biomarkers, & Prevention, 1999, 8(11), 1017.
  • Ghai, Nirupa Rajendra. Dietary Folate, Alcohol and the Risk of Breast Cancer. Thesis. New Haven, CT: Yale University, 2002.
  • Ginsburg, E.S. Estrogen, alcohol and breast cancer risk. The Journal of Steroid Biochemistry and Molecular Biology, 1999, 69(1-6), 299-306.
  • Hamajima, N., et al. Alcohol, tobacco and breast cancer- collaborative reanalysis of individual data from 53 epidemiological studies, including 58515 women with breast cancer and 95067 women without the disease. British Journal of Cancer, 2002, 87, 1234-1245.
  • Hankinson, Susan E. Prospective Analyses of Hormone Levels, Alcohol Intake, and Body Fat Distribution in Relation to Breast Cancer Risk. Ft. Belvoir: Defense Technical Information, 1998.
  • Hines, Lisa M., et al. Prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. Cancer Epidemiology, Biomarkers & Prevention, 2000, 9(10), 1099.
  • Holmberg L., Baron J. A., Byers T., et al. Alcohol intake and breast cancer risk: effect of exposure from 15 years of age. Cancer Epidemiology Biomarkers Prev. 1995; 4:843-847.
  • Jain, M.G., et al. Alcohol and breast cancer mortality in a cohort study. Breast Cancer Research and Treatment, 2000, 64(2), 201-209.
  • Kinney, A.Y., et al. Alcohol consumption and breast cancer among black and white women in North Carolina (United States). Cancer Causes & Control, 2000, 11(4), 345-357.
  • Key, Anne, et al. Meta-analysis of studies of alcohol and breast cancer with consideration of the methodological issues. Cancer Causes and Control, 2006, 17(6), 759-770.
  • Knight, Julia A., et a. Alcohol intake and cigarette smoking and risk of a contralateral breast cancer. American Journal of Epidemiology, 2009, 169(8), 962-968.
  • Kropp, S., et al. Low-to-moderate alcohol consumption and breast cancer risk by age 50 years among women in Germany. American Journal of Epidemiology, 2001, 154(7), 624-634.
  • Kuper, H., et al. Alcohol and breast cancer risk: the alcoholism paradox. British Journal of Cancer, 2000, 83(7), 949-951.
  • Kyate, Naa O. Cultural and Contextual Determinants of Alcohol Use Among African American Women: A Multidisciplinary Approach to Breast Cancer Risk. Ft. Belvoir: Defense Technical Information Center, 2007.
  • Lajous, M., et al. Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women. Cancer Causes and Control, 2006, 17(9), 1209-1213.
  • Larsson, S.C., et al. Folate and risk of breast cancer. Journal of the National Cancer Institute, 2007, 64-76.
  • Lash, Timothy and Aschengrau, Ann. Alcohol drinking and risk of breast cancer. Breast Journal, 2000, 6(6), 396-399.
  • Lenz, Sara K. A Population-Based, Case-Controlled Study of Breast Cancer andAlcohol Consumption amongPostmenopausal Women Living in Montreal, Quebec, Canada. Thesis. Montreal, Canada:McGill University, 2000.
  • Lenz SK, Goldberg MS, Labreche F, Parent M-E, Valois M-F (2002) Association between alcohol consumption and postmenopausal breast cancer. Cancer Causes and Control, 2002, 13:701-710.
  • Levi F., Pasche C., Lucchini F., La Vecchia C. Alcohol and breast cancer in the Swiss Canton of Vaud. European Journal of Cancer. 1996; 32A:2108- 2113.
  • Lew, J.Q., et al. Alcohol and risk of breast cancer by histologic type and hormone receptor status in postmenopausal women: the NIH-AARP Diet and Health Study. American Journal of Epidemiology, 2009, 170(3), 308-317.
  • Lewis, Sarah J., et al. Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk. Journal of the National Cancer Institute, 2006, 98(22), 1607-1622.
  • Li, Y., et al. Wine, liquor, beer and risk of breast cancer in a large population. European Journal of Cancer, 2002, 45(5), 843-850.
  • Longnecker M. P., Newcomb P. A., Mittendorf R., et al. Risk of breast cancer in relation to lifetime alcohol consumption. Journal of National Cancer Institute. 1995; 87:923-929.
  • Longnecker M.P., Paganini-Hill A., Ross R. K. Lifetime alcohol consumption and breast cancer risk among postmenopausal women in Los Angeles. Cancer Epidemiological Biomarkers Prev. 1995; 4:721-725.
  • Longnecker, M.P. The Framingham results on alcohol and breast cancer. American Journal of Epidemiology, 1999, 149(2), 102-104.
  • McPherson, K. Alcohol and breast cancer. European Journal of Cancer, 1998, 34(9), 1307-1308.
  • Mannisto, S., et al. Lifetime alcohol consumption and breast cancer: a case-control study in Finland. Public Health Nutrition, 2000, 3(1), 11-18.
  • Marcus, Pamela M., et al. The associations of adolescent cigarette smoking, alcoholic beverage consumption, environmental tobacco smoke, and ionizing radiation with subsequent breast cancer risk (United States). Cancer Causes and Control, 2000, 11(3), 271.
  • May, Cheryl E. Awareness of the Relationship between Alcohol Intake and Breast Cancer Risk among Cal Poly Students. Thesis. San Louis Obispo, CA: California Polytechnic State University, 2002.
  • Meara, J., et al. Alcohol, cigarette smoking and breast cancer. British Journal of Cancer, 1989, 60(1), 70-73.
  • Meng, Q., et al. Stimulation of cell invasion and migration by alcohol in breast cancer. Biochemical and Biophysical Research Communications, 2000, 273(2), 448-453.
  • Morch, L.S., et al. Alcohol drinking, consumption patterns and breast cancer among Danish nurses: a cohort study. European Journal of Public Health, 2007, 17(6), 624-629.
  • More details on alcohol and breast cancer. International Clinical Nutrition Review, 1998, 18(2), 115.
  • Murch, Lina. S., et al. Alcohol drinking, consumption patterns, and breast cancer among Danish nurses: a cohort study. European Journal of Public Health, 2007, 17(6), 624-629.
  • Nagata, C., et al. Alcohol drinking and breast cancer risk. Japanese Journal of Clinical Oncology, 2000, 37(8), 568-574.
  • Nielsen, N.R. and Gronbaek, M. Interactions between intakes of alcohol and postmenopausal hormones on risk of breast cancer. International Journal of Cancer, 2008, 122(5), 1109-1113.
  • Nomura, Abraham. Epidemiological Cohort Study of Diet and Life Style Factors among Hawaiian Women with Breast Cancer in Hawaii. Ft. Belvoir: Defense Technical Information, 1999.
  • Petri, A.L., et al. Alcohol intake, type of beverage, and risk of cancer in pre- and postmenopausal women. Alcoholism: Clinical & Experimental Research, 2004, 28(7), 1084-1090.
  • Platek, Mary E. Alcohol Consumption and Risk of Breast Cancer: An Epidemiological Investigation of Possible Mechanisms. Thesis. Buffalo, NY: State University of New York, 2008.
  • Reding, Kerryn and Malone, Kathleen. Alcohol consumption and survival after breast cancer. Cancer Epidemiology, Biomarkers & Prevention: A Publication of the American Association for Cancer Research, 2009, 18(3), 1012.
  • Rohan, T.E., et al. Alcohol consumption and risk of breast cancer: a cohort study. Cancer Causes and Control, 2000, 11(3), 239.
  • Rohan, T.E., et al. Dietary folate consumption and breast cancer risk. Journal of the National Cancer Institute, 2000, 92(3), 266-268.
  • Satomi, Y., et al. Induction of AP-1 activity by perillyl alcohol in breast cancer cells. Carcinogenesis, 1999, 20(10), 1957-1962.
  • Seitz, H.K. and Maurer, B. The relationship between alcohol metabolism, estrogen levels, and breast cancer risk, Alcohol Research &Health, 2007, 30(1), 42-43.
  • Shrubsole, Martha J. Folate and Breast Cancer. Ft. Belvoir: Defense Technical Information, 2004.
  • Shrubsole, Martha J., et al. Dietary folate and breast cancer risk: results from the Shanghai Breast Cancer Study. Cancer Research, 2001, 61(19), 7136-7141.
  • Silva, Idos S. Alcohol, tobacco and breast cancer: should alcohol be condemned and tobacco acquitted? British Journal of Cancer, 2002, 87(11), 1195-1196.
  • Singletary, K.W. and Gapstur, S.M. Alcohol and breast cancer: review of epidemiological and experimental evidence and possible mechanisms. JAMA: The Journal of the American Medical Association, 2001, 286(17), 2143.
  • Smith, T. Alcohol and breast cancer. New Zealand Medical Journal, 2008, 121(1272), 101-102.
  • Smith-Warner, S.A., et al. Alcohol and breast cancer in women: a pooled analysis of cohort studies. JAMA: the Journal of the American Medical Association, 1998, 279(7), 535.
  • Soerjomataram, I., et al. Did alcohol protect against death from breast cancer in Russia? Lancet, 2009, 374(9694), 975-976.
  • Stice, Ashley E. A Proposed Case-Control Study of Alcohol Intake and Breast Cancer in Women. Thesis. San Louis Obispo, CA: California Polytechnic State University, 2000.
  • Stoll, B.A. Review - Alcohol intake and late-stage promotion of breast cancer. European Journal of Cancer, 1999, 35(12), 1653.
  • Stolzenberg-Solomon, R.Z., et al. Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. American Journal of Clinical Nutrition, 2006, 83(4), 895-904.
  • Stuurmer, T., et al. Interaction between alcohol dehydrogenase II gene, alcohol consumption, and risk for breast cancer. British Joiurnal of Cancer, 2002, 87(5), 519-523.
  • Summaries for patients. Alcohol, postmenopausal hormone therapy, and breast cancer. Annals of Internal Medicine, 2002, 137(10), 143.
  • Swanson C. A., Coates R. J., Malone K. E., et al. Alcohol consumption and breast cancer risk among women under age 45 years. Epidemiology. 1997; 8:231-237.
  • Tan, Duan-Jun, et al. Alcohol drinking and breast cancer. Breast Cancer Online, 2006, 9(4), 1-11.
  • Terry, M.B., et al. Lifetime alcohol intake and breast cancer risk. Annals of Epidemiology, 2006, 16(3), 230-240.
  • Thygesen, L.C., et al. Use of baseline and updated information on alcohol intake on risk for breast cancer: importance of latency. International Journal of Epidemiology, 2008, 37(3), 669-677.
  • Tjonneland, A., et al. Alcohol intake and breast cancer risk: the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes and Control, 2007, 361-373.
  • Tjonneland, Anne, et al. Nutrition and cancer - lifetime alcohol consumption and postmenopausal breast cancer in Denmark: a prospective cohort study. Journal of Nutrition, 2004, 134(1), 173.
  • Tseng, Marilyn, et al. Calculation of population attributable risk for alcohol and breast cancer (United States). Cancer Causes and Control, 1999, 10(2), 119.
  • Vaeth, P.A.C. and Satariano, W.A. Alcohol consumption and breast cancer stage at diagnosis. Alcoholism: Clinical and Experimental Research, 1998, 22(4), 928.
  • van den Brandt P. A., Goldbohm R. A., van't Veer P. Alcohol and breast cancer: results from the Netherlands Cohort Study. American Journal of Epidemiology. 1995; 141:907-915.
  • Visvanathan, Kala, et al. Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer. Alcoholism: Clinical and Experimental Research, 2007, 31(3), 467-476.
  • Wright, Richard M. The Role of Molybdenum Hydroxylase Generated Free Radicals in Alcohol Induced Breast Cancer. Ft. Belvoir: Defense Technical Information, 2001.
  • Yu, Chu-Ling. Cigarette Smoking, Alcohol Consumption and Breast Cancer Risk. Thesis. New Haven, CT: Yale University, 1999.
  • Yu, H. and Berkel, J. Do insulin-like growth factors mediate the effect of alcohol on breast cancer risk? Medical Hypotheses, 1999, 52(6), 491-496.
  • Yu, H., et al. Alcohol consumption and breast cancer risk. JAMA: the Journal of the American Medical Association, 1998, 280(13), 1137.
  • Young-in, Kim. The Effects of Folate on the Development of Breast Cancer in a Chemical Rodent Model of Mammary Carcinogenesis. Ft. Belvoir: Defense Technical Information, 2002.
  • Zaridge, D., et al. Did alcohol protect against death from breast cancer in Russia? Authors' reply. The Lancet, 2009, 374(9694), 975-976.
  • Zhang, S., et al. Alcohol consumption and breast cancer risk in the Women's Health Study. American Journal of Epidemiology, 2007, 165(6), 667-676.
  • .Zhang, S. A prospective study of folate intake and the risk of breast cancer. JAMA: the Journal of the American Medical Association, 1999, 281(17), 1632-1637.
  • Zhang, Y., et al. Alcohol consumption and the risk of breast cancer: the Framingham Study revisited. American Journal of Epidemiology, 1999, 149(2), 93-101.
  • Zhang, Y., et al. "The Framingham results on alcohol and breast cancer." American Journal of Epidemiology, 1999, 149(2), 105.

References

  • 1. National Institute on Alcohol Abuse and Alcoholism. State of the Science Report on the Effects of Moderate Drinking. Washington, DC: National Institutes of Health, December 19, 2003.
  • 2. National Cancer Institute. Breast Cancer Risk Assessment Tool. cancer.gov/bcrisktool
  • 3. Ellison, R.C., et al. Exploring the relation of alcohol consumption to risk of breast cancer. American Journal of Epidemiology, 2001, 154(8), 740-747; Ashley, M.J., et al. Moderate drinking and health: Implications of recent evidence. Canadian Family Physician, 1997, 43, 687-694.
  • 4. Morch, L.S., et al. Alcohol drinking, consumption patterns and breast cancer among Danish nurses: a cohort study. European Journal of Public Health, 2007, 17(6), 624-629.
  • 5. Sturgeon, S.R., et al. Geographic variation in mortality from breast cancer among white women in the United States. Journal of the National Cancer Institute, 1995, 87, 1846-1853; UK Department of Health.advisorybodies.doh.gov.uk/pdfs/alcbrrev.pdf; Longnecker, M.P., et al, (1988) A meta-analysis of alcohol consumption in relation to risk of breast cancer. JAMA, 1988, 260, 652-656; Longnecker, M.P. Alcoholic beverage consumption in relation to risk of breast cancer: some observations on published case control studies. Journal of Clinical Epidemiology, 1994, 207-216
  • 6. Roth, A.D., et al. Alcoholic beverages and breast cancer: some observations on published cases control studies. Journal of Clinical Epidemiology, 1994, 47, 207-216.
  • 7. Meister, K.A., et al. The health effects of moderate alcohol intake in humans: An epidemiologic review. Critical Reviews in Clinical Laboratory Sciences, 2000, 37, 261-296.
  • 8. National Institute on Alcohol Abuse and Alcoholism. Alcohol Alert. No. 21, PH 345, 1993; Ellison, R.C., et al. Exploring the relation of alcohol consumption to risk of breast cancer. American Journal of Epidemiology, 2001,154(8), 740-747; Friedenrich,C.M., et al. A cohort study of alcohol consumption and risk of breast cancer. American Journal of Epidemiology, 1993, 137(5), 512-520; Nasca, P.C., et al. An epidemiological case-control study of breast cancer and alcohol consumption. International Journal of Epidemiology, 1990,19(3), 532-538; Longnecker, M.P., et al. A meta-analysis of alcohol consumption in relation to risk of breast cancer. JAMA: Journal of the American Medical Association, 1988, 260(5), 652-656; Longnecker, M.P., et al. Alcohol consumption in relation to risk of cancers of the breast and large bowel. Alcohol Health & Research World, 1992,16(3), 223-229; Jain, M.G., et al. Alcohol and breast cancer mortality in a cohort study. Breast Cancer Research and Treatment, 2000, 64(2), 201-209.
  • 9. American Cancer Society. What are the Risk Factors for Breast Cancer? American Cancer Society website, 2009.
  • 10. Clavel-Chapelon, F., et al. Alcohol consumption and breast cancer risk. IARC Science Publication, 2002,156,155-160; Colditz, G.A. and Rosner, B. (2000) Cumulative risk of breast cancer to age 70 years according to risk factor status. American Journal of Epidemiology, 2000,152, 950-964; Ellison, R.C., et al. Exploring the relation of alcohol consumption to risk of breast cancer. American Journal of Epidemiology, 2001,154, 740-747; Feigelson, H., et al. Alcohol, folate, methione and risk of incident breast cancer in the American Cancer Society Cancer Prevention Study II nutrition cohort. Cancer Epidemiology, Biomarkers & Prevention, 2003, 12, 161-164; Garland, M., et al. Alcohol consumption in relation to breast cancer risk in a cohort of United States women 25-42 years of age. Cancer Epidemiology, Biomarkers & Prevention, 1999, 8, 1017-1021; Gronbaek, M. Factors influencing the relation between alcohol and mortality-with focus on wine. Journal of Internal Medicine, 2001, 250, 291-308; Horn-Ross, P.L., et al. Recent diet and breast cancer risk: the California Teachers Study. Cancer Causes and Control, 2002,13, 407-415; Lash, T.L. and Aschengrau, A. Alcohol drinking and risk of breast cancer. Breast Journal, 2000, 6, 396-399; Rohan, T.E., et al. Alcohol consumption and risk of breast cancer: a cohort study. Cancer Causes and Control, 2000, 11, 239-247; Smith-Warner, S.A., et al. Alcohol and breast cancer in women: a pooled analysis of cohort studies. JAMA, 1998, 279,535-540; Chu, S.Y., et al. Alcohol consumption and the risk of breast cancer. American Journal of Epidemiology, 1989, 130(5), 867-877; Zhang, Y., et al. Alcohol consumption and risk of breast cancer: the Framingham study revisited. American Journal of Epidemiology, 1999,149, 93-101; Tjonneland, A., et al. Alcohol intake, drinking patterns and risk of postmenopausal breast cancer in Denmark. Cancer Causes and Control, 2003,14, 277-284; Schatzkin, A. et al. Alcohol consumption and breast cancer: a cross-national correlation study. International Journal of Epidemiology, 1987,18(1), 28-31; Webster, L.A., et al. Alcohol consumption and risk of breast cancer. Lancet, 1983, 2(8352):724–726; Wellness Facts. Wellness Letter (School of Public Health, University of California at Berkeley), 1999, 15(8),1; Petri, A.L., et al. Alcohol intake, type of beverage, and risk of cancer in pre- and post-menopausal women. Alcoholism: Clinical & Experimental Research, 2004, 28(7), 1084-1090.
  • 11. Baumgartner, K.B., et al. Is alcohol intake associated with breast cancer in Hispanic women? Ethnic Disease, 2002, 12, 460-469; Ranstam, J. and Olsson, H. Alcohol cigarette smoking, and the risk of breast cancer. Cancer Detection and Prevention, 1995, 19, 487-493; Kropp S, et al. Low-to-moderate alcohol consumption and breast cancer risk by age 50 years among women in Germany. American Journal of Epidemiology, 2001,154, 624-634.
  • 12. Cotterchio, M., et al. Hormonal factors and the risk of breast cancer according to estrogen- and progesterone-receptor subgroups. Cancer Epidemiology, Biomarkers & Prevention, 2003, 12, 1053; Nagata, Chisato, et al. Alcohol Drinking and Breast Cancer Risk: An Evaluation Based on a Systematic Review of Epidemiologic Evidence among the Japanese Population. Japanese Journal of Clinical Oncology, 2007, 37(8), 568-574.
  • 13. Parker-Pope, Tara. For women, confusion about alcohol and health. New York Times, October 9, 2007.
  • 14. http://www.cancer.govcancertopics/factsheets/ssites-types/ibc
  • 15. http://www.cancer.net/patient/Cancer+Types/Breast+Cancer+-+Inflammatory
  • 16. http://www.mayoclinic.com/health/inflammatory-breast-cancer/DS00632/DSECTION=4
  • 17. http://jco.ascopubs.org/cgi/content/full/26/15/2568
  • 18. http://www.springerlink.com/content/h749w061034h7655/
  • 19. http://www.mayoclinic.com/health/invasive-lobular-carcinoma/DS01063/DSECTION=risk%2Dfactors
  • 20. http://www.cancer.net/patient/Cancer+Types/Mastocytosis/Mastocytosis?cpsextcurrchannel=1
  • 21. http://cebp.aacrjournals.org/cgi/content/full/15/5/946
  • 22. http://www.cancer.gov/cancertopics/factsheet/Sites-Types/paget-breast
  • 23. http://books.google.com/books?id=wWVZ6mVFfwcC&pg=PA995&lpg=PA995&dq=risk++%22Phyllodes%22&source=bl&ots=XquzV5QnBi&sig=xy5kKEZYbVPOiy5hja7g9ph1vcc&hl=en&ei=6lECSqHsOdDgtge16bGSBw&sa=X&oi=book_result&ct=result&resnum=3
  • 24. http://breastcancer.about.com/od/types/tp/tnbc_risk_factors.htm
  • 25. http://info.rare-cancer.org/adenoid-cystic-carcinoma-breast.html
  • 26. http://www.encyclopedia.com/doc/1P3-356325351.html
  • 27. http://www.cancerbackup.org.uk/Cancertype/Breast/DCISLCIS/DCIS
  • 28. http://www.breastcancer.org/symposiums/dcis/basics.jsp
  • 29. http://www.facingourrisk.org/hereditary_cancer/hereditary_cancer_and_genetics.html.
  • 30. http://www.cancer.net/patient/Cancer+Types/Breast+Cancer+-+Metaplastic
  • 31. American Cancer Society (cancer.org/docroot/CRI/content/CRI_2_4_2X_Do_we_know_what_causes_male_breast_cancer_28.asp?sitearea=&level) and (http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_male_breast_cancer_28.asp?rnav=cri)
  • 32. Bailey, L.B. Folate, methyl-related nutrients, alcohol and the MTHFR 677C -->T polymorphous affect cancer risk: intake recommendations. Journal of Nutrition, 2003, 133, 37485-37535.
  • 33. Baglietto, Laura, et al. Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study. British Medical Journal, August 8, 2005.
  • 34. Baglietto, Laura, et al. Does dietary folate intake modify effect of alcohol consumption on breast cancer risk? Prospective cohort study. British Medical Journal (clinical research edition), 2005, 331(7520), 807.
  • 35. National Institute on Alcohol Abuse and Alcoholism. State of the Science Report on the Effects of Moderate Drinking. Washington, DC: National Institutes of Health, December 19, 2003.

Additional Information on Alcohol and Breast Cancer

  • Alcohol and Breast Cancer
    Dr. William Waddell describes some of the issues in the relationship between drinking alcohol and the risk of breast cancer.
  • Folate, Alcohol & Breast Cancer Risk
    A study of 17,000 women has found that women who consume about three drinks per day but take 200 micrograms of folate or folic acid (Vitamin B9) per day have a lower risk of breast cancer than do alcohol abstainers.
  • Folate, Alcohol, and Breast Cancer
    Women who drink alcohol and have a high folate intake are not at increased risk of breast cancer compared to those who abstain from alcohol, according to an exhaustive review of the research evidence.
  • Breast Cancer and Folic Acid
    Folic acid appears to offset the risk of breast cancer from alcohol among women who drink in moderation.
  • Moderate Drinking and Breast Cancer
    Moderate drinking of alcoholic beverages appears to have little effect on women's risk for breast cancer according to research at the Centre for Alcohol Research at the National Institute for Public Health in Denmark.
  • Alcohol and Breast Cancer
    New data from the ongoing Framingham study indicate that alcohol consumption does not increase the risk of breast cancer.
  • Alcohol and breast cancer in the elderly
    By the age of 80, breast cancer will affect 8.8 of every 100 women. One drink a day raises the risk about one percentage point.

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