Drinking Alcohol and Gallstone & Gallbladder Disease Risk

Are drinking alcohol and gallstone disease related? Yes. Drinking alcohol reduces the risk of developing gallstone and gallbladder disease.

alcohol and gallstone

Here is some of the research.

• Researchers followed 1,290,413 women in the UK for over six years. Drinking reduced the risk of developing gallstone disease. Those who had 15 or more drinks weekly had a 41% lower risk.  That’s compared to those who had one to two drinks weekly.1

• Investigators analyzed data on 58,462 Italians. The men and women adults were age 25 and over. Controlled were age sex and other factors. The researchers then compared drinkers to non-drinkers. Those who had up to about 1.3 drinks daily had a 17% reduced risk of gallstone disease. Those who had from 1.3 to 2.8 drinks daily had a 33% decrease. And those who had over 2.8 drinks daily showed a 42% drop in risk.2

• Researchers followed 88,837 women aged 34 to 59 for four years. They then analyzed the resulting data. Drinking alcohol and gallbladder disease were linked. Specifically, those who drank daily had a 40% decreased risk of gallbladder disease.3

• A study examined 29,584 Italian men. Researchers compared drinkers to non-drinkers. Daily moderate drinking greatly lowered their risk of gallstone disease. 4

• Researchers followed 80,898 women in the U.S. for 20 years. As drinking increased, risk of gallstone disease decreased. Compared to abstainers, women who consumed up to one drink daily had a 14% decrease in risk. Those who drank an average of four or more drinks per day had a 38% reduced risk. Increased frequency of drinking greatly decreased risk.5

• Investigators conducted a meta-analysis of observational studies of alcohol and gallstone disease. They analyzed data from eight cohort and 10 case-control studies. Higher alcohol consumption went with with lower risk of gallstone disease among both men and women.6


1. Liu, B., et al. Effects of alcohol and smoking on the risks of cirrhosis and gallbladder disease in middle-aged women. Am J Epid., 2008, 169(2), 153-160.
2. La Vecca, C., et al. Alcohol drinking and prevalence of self-reported gallstone disease in the 1983 Italian National Health Survey. Epid., 1994, 5(5), 533-6.
3. Maclure, K.M, et al. Weight, diet, and the risk of symptomatic gallstones in middle-aged women. New Eng J Med., 1989, 321, 563-569.
4. Attili, A.F., et al. Diet, and gallstones in Italy. Hepa., 1998, 27(6), 1492-1498.
5. Leitzmann, M.F., et al. Alcohol consumption in relation to risk of cholecystectomy in women. Am J Clin Nutri., 2003, 78(2), 339-347.
6. Wang J., et al. Alcohol consumption and risk of gallstone disease: a meta-analysis. Eur J Gastro Hepatol., 2016 Dec 6.

Resources on Alcohol and Gallstone & Gallbladder Disease

Bayram, C. et al. Gallbladder disease. Austral Fam Physician, 2013, 42(7), 443-458.

Ko, C. Gallbladder Disease. Philadelphia: Saunders, 2010.

Ruhl, C. Risk Factors for Gallbladder Disease. Diss, Johns Hopkins U, 2001.

Van Erpecum, K., et al. Gallstone Disease. Amsterdam : Elssevier, 2006.

Nat Inst Health Care Excell. Gallstone Disease. London: The Institute, 2015.

Coyne, M. and Schoenfield, L. Gallstone disease. Postgrad Med, 2016, 57(1), 153-159